![]() Some groups have had success treating MS using bone marrow transplants. ![]() About 400,000 people are living with MS in the U.S. Over time the disease progresses and people may end up with more severe symptoms included paralysis. As people lose myelin surrounding their nerves they start feeling weak or having trouble walking. This protective covering is called myelin. Multiple sclerosis occurs when the body’s own immune system attacks the cells that surround and protect neurons. funds many projects seeking to better understand multiple sclerosis and to translate those discoveries into new therapies. Autologous hematopoietic stem cell transplantation in multiple sclerosis: A meta-analysis. Autologous haematopoietic stem cell transplantation (aHSCT) for severe resistant autoimmune and inflammatory diseases - a guide for the generalist. Stem cell therapies for progressive multiple sclerosis. A review on stem cell therapy for multiple sclerosis: Special focus on human embryonic stem cells. Cell-based therapeutic strategies for multiple sclerosis. Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis. journals/jamaneurology/article-abstract/2771920 ![]() Recommendations of the National Multiple Sclerosis Society. Autologous hematopoietic stem cell transplant in multiple sclerosis. Mesenchymal stem cells for multiple sclerosis: Hype or hope? /journals/laneur/article/PIIS1474-4422(21)00324-0/fulltext fda.gov/consumers/consumer-updates/fda-warns-about-stem-cell-therapies FDA warns about stem cell therapies (2019).fda.gov/vaccines-blood-biologics/consumers-biologics/consumer-alert-regenerative-medicine-products-including-stem-cells-and-exosomes Consumer alert on regenerative medicine products including stem cells and exosomes.Effect of nonmyeloablative hematopoietic stem cell transplantation vs continued disease-modifying therapy on disease progression in patients with relapsing-remitting multiple sclerosis. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. However, the higher efficacy treatments (such as Ocrevus, Alemtuzumab) were not included in that research analysis. Stem cell therapy may be more effective at increasing the time it takes for MS to progress, compared with standard MS treatments. This compared with 9.7% in a placebo group. During a 1-year follow-up, 58.6% of the MSC-IT group and 40.6% of the MSC-IV group exhibited no evidence of disease activity. Doctors treated some intrathecally (IT), which means administering it into the spinal cord. A 2020 clinical trial involved mesenchymal stem cell (MSC) therapy in 48 people with progressive MS.Study authors cited the need for larger, more rigorous trials to compare the benefits of stem cell therapy versus the latest DMTs. ![]() A 2021 review article found that aHSCT may benefit people with relapsing and active forms of MS.At 5 years, 67% still had no evidence of disease activity. Two years after therapy, 83% of participants had no evidence of disease activity. A 2017 analysis looked at 15 aHSCT trials involving people with MS.Researchers are looking into many types of stem cells that might help people with MS.īut most studies focus on autologous hematopoietic stem cell transplantation (aHSCT). ![]()
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